Salts and solid form of a BTK inhibitor

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专利权人:

PRINCIPIA BIOPHARMA INC.

发明人:

Masjedizadeh Mohammad Reza,Gourlay Steven

申请号：

US201515120293

公开号：

US10092569(B2)

申请日:

2015.02.20

申请国别(地区):

美国

年份:

2018

代理人:

Finnegan, Henderson, Farabow, Garrett & Dunner, LLP

摘要：

Disclosed herein are processes for preparing 2-[(3R)-3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile free base (compound (I)), salts of compound (I) and solid state form of said salts. Also disclosed herein are pharmaceutical compositions comprising such salts and solid state form thereof and methods of treating cancer, autoimmune, and inflammatory diseases using compound (I) or a pharmaceutically acceptable salt thereof.

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中国工程科技知识中心

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http://www.ckcest.cn/home/