Lindsay Edward Wu,David Andrew Sinclair,Abhirup Das
申请号：
US16471653
公开号：
US20190328761A1
申请日:
2017.12.21
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to methods of increasing vascular density and/or blood flow in tissue of a subject, and to increasing exercise capacity of a subject, the methods include administering to a subject an effective amount of an agent that elevates SIRT1 activity in endothelial cells of the subject, the invention further includes administering an NAD+ agonist or NAD+ precursor to a subject to increase vascular density and/or blood flow. The invention includes compositions comprising the said agent.
