The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals, including humans. The compounds and compositions may be used for combating parasites in or on animals including mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in animals, including birds and mammals.本發明提供式(I)環狀酯肽化合物及包含該等化合物之組合物,其等可有效對抗會傷害包括人類之動物之寄生蟲。該等化合物及組合物可用於對抗包括哺乳動物及鳥類之動物中或動物上寄生蟲。本發明亦提供一種用於根除、控制及預防包括鳥類及哺乳動物之動物中寄生蟲傳染的改良方法。