The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.本發明提供式(I)之環狀酯肽化合物及包含該等化合物之組合物,該等化合物及組合物可有效抵抗危害動物之寄生蟲。該等化合物及組合物可用於對抗哺乳動物及鳥類體內或體表之寄生蟲。本發明亦提供根除、控制及預防鳥類及哺乳動物中寄生蟲侵擾之改良方法。