HARRI SALO,PETERIS PRUSIS,MATTIAS ROSLUND,TERHI HEIKKINEN,RIINA ARVELA,PATRIK HOLM
申请号：
ARP130103538
公开号：
AR092749A1
申请日:
2013.09.30
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Compounds used to treat diabetes, various pain, hepatitis C and inflammation. 1. Requirement 1: a compound (1) with formula characteristics,a. A and B together with the atoms to which they are attached form the selected remainder of a set of formulas (2)；where atoms marked with * and * bind to the main molecular unit； X is CR⁵ or N； Y is CR⁶ or N； Z is CR⁴ or N, with the proviso that when Y or X is N, then Z is not N； R¹ is C₁₋₆ alkyl,C₃₋₆ cycloalkyl,C₁₋₆ haloalkyl,alcoxi C alquilo Chaloalkoxy C₁₋₆alkyl C₁₋₆,1. C832188331-s-acquilo c83218c8326；3. Isopropene, isoacrylonitrile c832131；phenyl, C₁₋₃ phenylalkyl,phenoxyalkyl C₁₋₆,where said C₃₋₆ cycloalkyl,a. Non-n-propene or phenyl has not been replaced or replaced with 1 or 2 substitutes, each of which is a halogen, tar c831832525；C₁₋₅ haloalkyl,C₁₋₅ alkoxy,C₃₋₆ cycloalkyl,CN haloalcoxi C₁₋₅；alquil C₁₋₅-S-,alquil C - (S 3DO) -o alquil C - (O 3DS 3DO) -R² is C₁₋₆ alkyl；R³ is C₁₋₆ alkyl；R8308es h, halogen, tar c832131；C₁₋₆ alkoxy,C₁₋₆ haloalkyl,hello Coxi C₁₋₆,C₁₋₆ alkoxy C₁₋₆ alkoxy,1. C83218331 asphalt-s -,alquil C amino haloalquil C amino alquil C - (C 3DO)CN, or heterocyclyl； R⁵ is H, halogen, C₁₋₆ alkyl,C₃₋₆ cycloalkyl,C₁₋₆ alkoxy,C₁₋₆ haloalkyl,alcoxi C alquilo Chello Coxi C₁₋₆,C₁₋₆ alkoxy C₁₋₆ alkoxy,1. C83218331 asphalt-s -,alquil C - (S 3DO) -alquil C - (O 3DS 3DO) -haloalquil C₁₋₆-S-,halo C₁₋₆amino alkyl, C₁₋₆- (C = O) alkyl,or CN； and R⁶ is H, halogen, C₁₋₆ alkyl,or C₁₋₆ haloalkyl；or R¹ and R⁶ form, together with the atoms to which they are attached, a saturated or unsaturated condensed heterocyclic ring of 5 or 6 members which contains, in addition to the nitrogen atom to which R¹ is attached, 0 or 1 additional heteroatom selected from N , O, and S, wherein said heterocyclic ring is not substituted or is substituted with 1 or 2 substituent (s) where each independently is C₁₋₂ alkyl or halogen； or R⁴ and R⁵ form, together with the carbon atoms of the ring to which they are attached, a saturated, unsaturated or
