IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
发明人:
SIDENIUS NICOLAI
申请号：
NZ61260811
公开号：
NZ612608A
申请日:
2011.12.21
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a dimeric molecule comprising two polypeptides selected from the group of: - a first polypeptide comprising the growth factor-like domain of Urokinase-type plasminogen activator (uPA) (GFD domain)； and - a second polypeptide comprising the somatomedin B domain of protein vitronectin (VN) (SMB domain)； wherein the two polypeptides are linked one to the other by a molecular scaffold, and wherein the dimeric molecule inhibits the urokinase-type plasminogen activator receptor (uPAR).
