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Morpholine-pyridine derivative
专利权人:
エフ.ホフマン-ラ;アーゲー;ロシュ;エフ.ホフマン-ラ ロシュ アーゲー
发明人:
ガレイ,グイド,フリジェ,フィリップ,ノークロス,ロジャー,チェチェーレ,ジュゼッペ,シェン,ホン,フウ,イミン,ガレイ,グイド,フリジェ,フィリップ,ノークロス,ロジャー,チェチェーレ,ジュゼッペ,シェン,ホン,フウ,イミン
申请号:
JP2016564587
公开号:
JP6255516B2
申请日:
2015.04.27
申请国别(地区):
JP
年份:
2017
代理人:
摘要:
The present invention relates to compounds of formula (I) wherein X is CR or N; R is hydrogen, halogen or lower alkyl; L is a bond, -C(O)- or -C(O)NH-; Ar is phenyl or a five or six membered heteroaryl group, containing one or two N atoms; R1 is halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen or cycloalkyl; n is 0, 1, 2 or 3; or to a pharmaceutically suitable acid addition salt thereof, to all racemic mixtures, all their corresponding enantiomers and/or optical isomers, which may be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse, metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.
来源网站:
中国工程科技知识中心
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