GALLEY, GUIDO,GROEBKE ZBINDEN, KATRIN,NORCROSS, ROGER,STALDER, HENRI
申请号：
UAA200908758
公开号：
UA98951C2
申请日:
2008.01.23
申请国别(地区):
UA
年份:
2012
代理人:
摘要：
The invention relates to the use of compounds of Formula (I) wherein R is hydrogen, deuterium, tritium, lower alkyl, lower alkoxy, lower alky] substituted by halogen, lower alkoxy substituted by halogen, halogen, phenyl optionally substituted by halogen, or is phenyloxy, benzyl, benzyloxy, -COO-lower alkyl, -O-(CH)-O-lower alkyl, NH-cycloalkyl, cycloalkyl or tetrahydropyran-4-yloxy, wherein the substituents for n>； 1 may be the same or different； X is a bond, -CHR-, -CHRCHR&rsquo；-, -OCH-, -CHOCHR-, -CHCHCH-, -SCH-, -S(O)CH-, -CHSCH-, -CHN(R)CH-, -cycloalkyl-CH- or SiRR'-CH-； R/R' may be in- dependently from each other hydrogen, lower alkyl or lower alkyl substituted by halogen； Ris hydrogen, phenyl or lower alkyl； Y is phenyl, naphthyl, thiophenyl, pyridinyl, cycloalkyl, 1,2,3,4-tetrahydro-naphthalen-2-yl, 2,3-dihydrobenzo[1,4]dioxin-6-yl or, benzo[1,3]dioxol-5-yl； n is 0, 1, 2 or 3； o is 2 or 3； or to a pharmaceutically suitable acid addition salt for the manufacture of medicaments for the treatment of diseases related to the biological function of the trace amine associated receptors, which diseases are depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, sub-) stance abuse and metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.Винахід стосується застосування сполук формули (І),деRявляє собою атом водню, дейтерій, тритій, нижчий алкіл, нижчий алкокси, нижчий алкіл, заміщений атомом галогену, нижчий алкокси, заміщений атомом галогену, атом галогену, феніл, можливо заміщений атомом галогену, або являє собою фенілокси, бензил, бензи
