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低色素症の改善及び脂肪形成抑制効能を有するペプチド及びその用途
专利权人:
ケアジェン カンパニー,リミテッド
发明人:
チョン・ヨンジ,キム・ウンミ,リ・ウンジ,チョ・ギョンミ
申请号:
JP2016565255
公开号:
JP6352445B2
申请日:
2014.11.21
申请国别(地区):
JP
年份:
2018
代理人:
摘要:
A peptide formed from the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, according to the present invention, shows a melanogenesis increment activity and an adipogenesis inhibitory activity. A peptide of the present invention, by increasing phosphorylation of MITF, which is a transcription factor for increasing a tyrosinase expression, and CREB for increasing an MITF expression, consequently increases a tyrosinase expression and ultimately increases melanin synthesis. A peptide of the present invention, by reducing the amount of fat accumulated inside a cell and reducing expressions of perilipin and PPAR³, which contribute to adipogenic mechanism, ultimately inhibits adipogenesis. The present invention provides a composition for remedying or treating melanin hypopigmentation, the composition comprising the peptide, and provides pharmaceutical composition for treating or preventing obesity.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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