Sloan-Kettering Institute for Cancer Research;Novartis AG
发明人:
Daniel, Dylan,Joyce, Johanna,Sutton, James
申请号：
AU2012250574
公开号：
AU2012250574B2
申请日:
2012.05.04
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The present invention provides a compound of formula I； where in R1 is an alkyl pyrazole or an alkyl carboxamide, and R2 is a hydroxycycloalkyl； or a pharmaceutically acceptable salt thereof, and compositions containing these compounds, for use to treat a brain tumor, particularly glioblastoma. The invention provides effective treatment of a brain tumor and can be used by oral administration of a compound of Formula I as further described herein. Gene signatures correlated with successful treatment using these methods are also disclosed.
