Novartis AG;Sloan-Kettering Instiute for Cancer Research
发明人:
DANIEL Dylan,JOYCE Johanna,SUTTON James
申请号：
SI201230916
公开号：
SI2704713T1
申请日:
2012.05.04
申请国别(地区):
SI
年份:
2017
代理人:
摘要：
The present invention provides a compound of formula I； wherein R1 is an alkyl pyrazole or an alkyl carboxamide, and R2 is a hydroxycycloalkyl； or a pharmaceutically acceptable salt thereof, and compositions containing these compounds, for use to treat a brain tumor, particularly glioblastoma. The invention provides effective treatment of a brain tumor and can be used by oral administration of a compound of Formula I as further described herein. The invention also provides a method to treat a subject having a brain tumor such as glioblastoma, wherein the method comprises administering to the subject an effective amount of a compound of Formula I. Gene signatures correlated with successful treatment using these methods are also disclosed.
