STINCHCOMB DAN T.,OSORIO JORGE E.,PARTIDOS CHARALAMBOS D.,BREWOO JOSEPH N.
申请号：
NZ59700010
公开号：
NZ597000A
申请日:
2010.05.28
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed is a use of a mixture of three or more different dengue-dengue chimeras of live, attenuated dengue viruses of three or more serotypes in the manufacture of a single immunogenic composition for inducing an immune response in a subject in need thereof, wherein said medicament is formulated for at least a first intradermal administration. Further disclosed is a composition for inducing an immune response in a subject against three or more dengue virus serotype comprising, an intradermally (ID) administered single dose composition of predetermined ratio of at least three attenuated dengue virus serotypes wherein the composition comprises three or more different dengue-dengue chimeras of live, attenuated dengue viruses of three or more serotypes. Further disclosed is a vaccine kit comprising a single composition of a mixture of three or more different dengue-dengue chimeras of live, attenuated dengue viruses of three or more dengue virus serotypes； and at least one apparatus capable of intradermal administration of the composition to a subject.
