XUEDONG DAI,NOA ZERANGUE,PETER A VIRSIK,ARCHANA GANGAKHEDKAR
申请号：
NZ60819609
公开号：
NZ608196A
申请日:
2009.08.19
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed are prodrugs of methyl hydrogen fumarate (monomethyl fumarate) according to formula (I), and methods for their preparation. Specific examples of compounds of formula (I) include: (2E)-3-[(2-morpholin-4-yl-2-oxoethyl)oxycarbonyI]prop-2-enoic acid (2E)-3-{ [(N,N-diethylcarbamoyl)methyI]oxycarbonyl} prop-2-enoic acid (2E)-3-({ [N-benzylcarbamoyI]methyl} oxycarbonyl) prop-2-enoic acid. Compounds of formula (I) are useful for treating psoriasis, asthma, chronic obstructive pulmonary disease, cardiac insufficiency, left ventricular insufficiency, myocardial infarction, angina pectoris, Parkinson&rsquos disease, Alzheimer&rsquos disease, Huntington&rsquos disease, retinopathia pigmentosa, mitochondrial encephalomyopathy, transplantation rejection, multiple sclerosis,ischemia, reperfusion injury, AGE induced genome damage, inflammatory bowel disease, Crohn&rsquos disease, or ulcerative colitis.
