The present invention relates to a nanoparticle-vitreous-based protein complex, and more specifically, a composition for inhibiting angiogenesis, a composition for preventing or treating angiogenesis-related diseases or retinal diseases comprising the complex as an active ingredient. About. The nanoparticle-vitreous matrix protein complex according to the present invention exhibits a remarkably excellent binding force with vascular endothelial growth factor when locally injected into the vitreous cavity, and can suppress angiogenesis, so that the retina and choroidal neovascularization It can be easily used for the production of therapeutic agents for the prevention, amelioration or treatment of related diseases. [Selection] Figure 9本発明は、ナノ粒子－硝子体基盤タンパク質複合体に関し、より具体的には、前記複合体を有効成分として含む血管新生抑制用組成物、血管新生関連疾患または網膜疾患の予防または治療用組成物に関する。本発明によるナノ粒子－硝子体基盤タンパク質複合体は、硝子体腔内に局所注射時、血管内皮細胞成長因子と顕著に優れた結合力を示して、血管新生を抑制できるので、網膜および脈絡膜血管新生関連疾患の予防、改善または治療のための治療剤などの製造に容易に使用され得る。【選択図】図９
