The invention relates to an oil-in-water nanoemulsion for MRI, including:an aqueous phase,a fluorinated phase including at least one fluorinated oil,a surfactant at the interface between the aqueous and fluorinated phases, the surfactant comprising: at least one amphiphilic targeting ligand,at least one amphiphilic lipid, andat least one diblock or triblock fluorophilic compound,as well as to the use thereof as a contrast agent.