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PROCÉDÉ DE PRÉPARATION D'AGENT DE CONTRASTE POUR IMAGERIE PAR RÉSONANCE MAGNÉTIQUE
专利权人:
Enzychem Lifesciences Corporation
发明人:
申请号:
EP16855801.3
公开号:
EP3363466A1
申请日:
2016.10.17
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention relates to a method for preparing a contrast agent for magnetic resonance imaging (MRI) and, more particularly, to a method for preparing a contrast agent for magnetic resonance imaging, which has improved stability by minimizing side effects by removing unreacted substances generated during a preparation process. The preparation method comprises the steps of: reacting a lanthanide with a macrocyclic chelate to form a complex-containing aqueous solution; exchanging ions using one or more resins among a cation-exchange resin, a chelate resin and an anion-exchange resin in order to remove free lanthanide and unreacted macrocyclic chelate from the complex-containing aqueous solution; controlling pH of the complex aqueous solution in a neutral range; and removing germs from the complex aqueous solution.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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