Ex vivo animal or challenge model as method to measure protective immunity directed against parasites and vaccines shown to be protective in the method
Florine Johanna van Milligen,Johannes Bernardus Wilhelmus Joseph Cornelissen,Bernard Adri Bokhout
申请号：
US13373428
公开号：
US20120107342A1
申请日:
2011.11.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Described is an ex vivo animal or challenge model used as a method to identify protective (e.g., recombinant) proteins and rapidly measure protective immunity in intestinal segments directed against parasites and vaccines directed against parasitic infections. Further described are vaccines directed against infection with parasites, such as Fasciola hepatica, which vaccines contain protective (recombinant) proteins identified and shown to be protective in studies using the ex vivo model. Further described are protective (e.g., recombinant) proteins obtained from newly excysted juveniles (NEJ) of F. hepatica. The protective (recombinant) protein corresponding to an NEJ protein has an apparent molecular weight of 32 kD and an N-terminal amino acid molecule comprising the sequence XXDVSWPFWDRMYNY (SEQ ID NO:1).
