PROBLEM TO BE SOLVED: To provide a method for producing a tablet capable of holding stably for a long period, candesartan cilexetil which is unstable to an impact or a pressure applied during formulation.SOLUTION: One or two or more kinds selected from a group consisting of binders and plasticizers are dissolved or suspended into water, and powdery candesartan cilexetil whose average particle size is 5-500 &mum is added thereto, and then crushed by a wet type crushing method to obtain uniform dispersion of candesartan fine powder, and granulation is performed by using the dispersant and an additive, followed by compression molding, to thereby obtain this tablet.COPYRIGHT: (C)2012,JPO&INPIT【課題】製剤時に加えられる衝撃や圧力に対し不安定なカンデサルタンシレキセチルを、長期間安定に保持できる錠剤の製造方法を提供する。【解決手段】結合剤と可塑剤からなる群から選ばれた1種又は2種以上を水に溶解ないし懸濁させ、これに平均粒子径が5μm~500μmの粉末状カンデサルタンシレキセチルを加えて湿式粉砕法により粉砕処理することにより、カンデサルタン微粉末の均一分散液とし、これと添加剤を用いて造粒し、圧縮成型して錠剤を得る。【選択図】なし
