MEIJBOOM, RONALD,VAN MIDWOUD, PAUL MARCEL,VAN DIJK, MAARTEN,FLIPSEN, THEODORUS ADRIANUS CORNELIUS,DE BOEF, ESTHER
申请号：
CA3003768
公开号：
CA3003768A1
申请日:
2016.11.04
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The invention relates to a composition comprising a) 55-98.9 wt% of at least one type of triblock copolymer (A) of formula (1) R-B-A-B-R b) 0.1-15 wt% of at least one surfactant (B) and c) 1-30 wt% of water, wherein A is a hydrophilic block having a number average molecular weight (Mn) of 100-1,000 Da, B is a hydrophobic block made from monomers comprising at least a monomer B1 and a monomer B2, wherein B1 and B2 have the largest weight contents in the hydrophobic block and B1 has a lower molecular weight than B2, wherein R is an end group which is H or a C1-C30 organic moiety, wherein the composition is fluid in a temperature range of 0°C to 37°C, wherein the weight % are relative to the sum of a), b) and c), and wherein the sum of components a), b) and c) is at least 80 wt% of the entire composition, preferably at least 90 wt%； to the use of the composition and to pharmaceutical compositions comprising said composition and an active pharmaceutical ingredient.
