The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidases.本發明係關於具有尿酸分解活性之基因修飾蛋白質。更特定而言,本發明係關於包含經截斷尿酸氧化酶之蛋白質及其製備方法,該蛋白質包括包含經截斷尿酸氧化酶之經聚乙二醇化蛋白質。