The disclosure relates to a lyophilized pharmaceutical preparation comprising melphalan flufenamide hydrochloride (J1) and at least one excipient selected from the group comprising sulfobutylether-B-cyclodextrin； Trehalose and Sucrose. The preparation may comprise two excipients. The disclosure also relates to a method of manufacture of this composition, a kit of parts comprising these features, the preparation of this pharmaceutical and the use of this pharmaceutical in the treatment of cancer.
