The present invention relates to crystalline salts of betrixaban and processes for their preparation. More specifically, it relates to crystalline betrixaban hydrochloride, crystalline betrixaban citrate and to crystalline form B of betrixaban hydrobromide. It also relates to a pharmaceutical composition comprising said crystalline salts of betrixaban and one or more pharmaceutically acceptable excipients. The invention also concerns the use of said pharmaceutical compositions as a medicament, in particular for the prevention and the treatment of disease conditions characterized by undesired thrombosis.