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調節可能な生体吸収性ゾル-ゲル誘導型SiO2を調製する方法
专利权人:
デルシテク オサケ ユキチュア
发明人:
ヨキネン、ミカ,ヴィタラ、レータ,ヤロネン、ハリー
申请号:
JP2007500241
公开号:
JP5227017B2
申请日:
2005.02.22
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
Relates to a method for preparing a gel derived SiO 2, sol - sol - with bio-resources option a very fast rate the present invention, the gel derived SiO 2, water, inorganic silicate or alkoxide using a base or mineral acid as a catalyst and are prepared from a sol containing a lower alcohol, and dried the sol was aged. The feature of the method, from 1.5 to 2.5, the molar ratio of inorganic silicate or water to alkoxide in 0.5~2.5, pH is 0.5 or higher molar ratio of inorganic silicates or alcohol to alkoxide induces a change in the composition or, allowed to gel without forced drying of the sol and without induced changes in the composition of the sol and, there, forced drying of the sol starts or takes place within 30 minutes after induced changes It is to be. The present invention sol - also relates to a method for adjusting the bio-resource option speed gel derived SiO 2. SiO 2 with a bio-resources option a very fast rate is obtained by the method in question above, features for adjustment method, some of the parameters SiO 2 with a bio-resources option a slower rate than the earliest bio-resources subscription rate is obtained by varying the. The induced changes due to the addition of the agent or agents biologically active / or any molar ratio of inorganic silicate or alcohol to alkoxide and / or a molar ratio pH, inorganic silicate or water-to-alkoxide, and the component or components, By varying the temperature by performing affect the change in value due to the start prevent forced drying, or perform a forced drying of the sol or after, and in order to gel naturally or sol / there. Bioresorbable sol obtained by the methods of the invention The present invention - relates to a gel derived SiO 2, the use of the drug administration biologically active.本発明は、非常に早いバイオリソープション速度を有するゾル-ゲル誘導SiO2を調製するための方法に関し、ゾル-ゲル誘導SiO2は、触媒として鉱酸または塩基を用いて水、アルコキシドまたは無機シリケートおよび低級アルコールを含有するゾルから調製され、前記ゾルは熟成し乾燥される。該方法の特徴は、pHは1.5から2.5、水対アルコキシドまたは無機シリケートのモル比が0.5~2.5で、アルコール対アルコキシドまたは無機シリケートのモル
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