A new and distinct cultivar of Caladium plant named ‘；Heart and Soul’；, characterized by its short to intermediate height； upright and mounding plant habit； dense and bushy appearance； vigorous growth habit and rapid growth rate； lance-type leaves that are dark green in color with greyed purple-colored venation, white, green, red and greyed purple-colored interveinal areas, and dark red-colored random spots； undulate margins give a ruffled appearance to the leaves； and petioles that are light greyed red to light greyed orange in color with greenish brown-colored stipples and streaks.
