ABRAHAM BOUT,RONALD HENDRIK PETER BRUS,PATRICIUS HENDRIKUS VAN BERKEL,TON LOGTENBERG
申请号：
PT10186063
公开号：
PT2314629E
申请日:
2003.07.15
申请国别(地区):
PT
年份:
2014
代理人:
摘要：
The invention provides methods for producing mixtures of antibodies from a single host cell clone. Thereto, a nucleic acid sequence encoding a common light chain, and nucleic acid sequences encoding two different heavy chains are expressed in a recombinant host cell. The antibodies in mixtures according to the invention comprise two different heavy chains capable of pairing to a common light chain, thereby forming functional antigen binding domains. Mixtures of antibodies, and use of these mixtures in a variety of field, are also provided by the invention.
