Patricius Hendrikus Van Berkel,Ronald Hendrik Peter Brus,Ton Logtenberg,Abraham Bout
申请号：
US13795637
公开号：
US20130243773A1
申请日:
2013.03.12
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Provided is methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
