The present invention relates generally to compositions and methods of using compositions comprised of undenatured cartilage in the form of an isolated native Type II collagen that may be combined in a synergistic blend with one or more edible metals with acceptable chemical counter-ions or other health promoting ingredients to be orally consumed as a method for preventing and improving symptoms of musculoskeletal distress degeneration, including symptoms selected from temporary loss of range of motion, temporary inflammation, temporary muscle soreness, and combinations thereof. The synergistic compositions of the present invention also protect, promote and improve recovery from and prevention of cartilage and ligament wear, thinning and damage to bone, and repetitive motion injuries and stress resulting from intense periods of activity or workout routines that contribute to such musculoskeletal distress degeneration symptoms.
