The present invention provides a compound which indicates a histamine H4 receptor modulating activity.A compound represented by a formula (I):whereinA ring is a ring represented by the following formula:whereinR1 is substituted or unsubstituted alkyl, etc., W is —O—, etc., n is an integer of 0 to 6；X is —N(R7)— or —O—； R7 is hydrogen, substituted or unsubstituted alkyl, etc.； Y is —C(R8)═ or —N═； R8 is hydrogen, substituted or unsubstituted alkyl, etc.； Z is ═O, ═S, etc.；B ring is a ring represented by the following formula:whereinR10 is each independently substituted or unsubstituted alkyl, halogen, hydroxy, substituted or unsubstituted alkyloxy, substituted or unsubstituted amino； R11, R12a and R12b are each independently hydrogen or substituted or unsubstituted alkyl, etc.；p is an integer of 0 to 4, or its pharmaceutically acceptable salt, or a solvate thereof.
