GRIFFITH DAVID C,RODNY OLGA,SURBER MARK W,BOSTIAN KEITH A,DUDLEY MICHAEL N
申请号：
NZ63146909
公开号：
NZ631469A
申请日:
2009.10.06
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
The present disclosure relates to the field of antimicrobial agents. In particular, the present disclosure relates to the use of aerosolized fluoroquinolones formulated with divalent or trivalent cations and having improved pulmonary availability for the treatment and management of bacterial infections of the lung and upper respiratory tract. In particular the use of a solution comprising levofloxacin and a magnesium cation for the preparation of an aerosol for treating a pulmonary infection caused by Pseudomonas aeruginosa in a human with cystic fibrosis, wherein the solution comprises a magnesium cation concentration from about 100 mM to about 250 mM, and a levofloxacin concentration from between about 90 mg/ml to about 125 mg/ml.
