Processes for the preparation of said compounds, intermediates used in the preparation of said compounds and the uses of said compounds to treat inflammatory skin diseases are also described. Claim 1: A compound of the formula (1) wherein R¹ and R² are independently selected from hydrogen, CO₂-C₁₋₄ alkyl,1. Lease land No. c833218331 and 832626；a. Alquenilo c832283316a and acquinio c832283316a；In these groups, the residues of asphalt, starch and asphalt can be linear chain, separator or combination of linear chain and formula (2), n is 0-3, formula (3) is 1-2, cyclo-c833318327；a three to twelve membered heterocyclic ring containing up to 3 heteroatoms where the heteroatoms are independently selected from N, O and S and where each heterocyclic ring may be optionally substituted on one or more carbon atoms by 1 to 3 substituents that are independently selected of C₁₋₆ alkoxy and O-C₁₋₆ alkyl；R³ and R⁴ are independently selected from hydrogen and C₁₋₆ alkyl；R83099a and r8310a should be independent of hydrogen and - co8322； - c8324； - h8329；A is selected from a covalent bond, O, S, Se, C₁₋₆ alkyl and (CH₂) ₙO, where n is an integer from 0 to 3； X is selected from a covalent bond, O, S and Se； B is selected from a covalent bond, -CH₂,-CH₂-CH₂-,-CH₂-CH₂-CH₂-,trans-CH = CH-,cis-CH = CH-,-C...-CHR⁷-CHR⁸-,Cis or trans-cr8311 = cr831221 -,where R⁷ and R⁸ are independently selected C alquilo alkyl,C₂₋₆ alkenyl,C₂₋₆ alkynyl and C₃₋₇ cycloalkyl；and Y is selected from OH, SH, OR⁹ where R⁹ is C₁₋₆ alkyl,a. Alquenilo c832283316a and acquinio c832283316a；C₃₋₇ and - (CH₂) ₙOH cycloalkyl, where n is an integer from 1 to 6 and NR⁹R¹⁰ where R⁹ and R¹⁰ are independently selected from C₁₋₆ alkyl and C₃₋₇ cycloalkyl；Or a salt that's medically acceptableTambién se describen procesos para la preparación de dichos compuestos, intermedios usados en la preparación de dichos compuestos y los usos de dichos compuestos para tratar enfermedades inflamatorias de la piel. Reivindicación 1: Un compuest
