Disclosed is a multi-region work control system, comprising a plurality of conducting wire circuits, a control module, and a self-moving working device. The working region includes a plurality of subunit, a conducting wire being arranged along the boundary of each subunit. The control module is configured to control an electric signal transmitted in the conducting wire circuit corresponding to the subunit in the working region. The self-moving working device is configured to cut the working region. In the system, by partitioning, the self-moving working device firstly returns back to a preset point, and then enters a corresponding region to work according to the electrical signal transmitted in the conducting wire circuit, thereby avoiding repeatedly working in a certain region from beginning to end or missing a certain region. The system is capable of selecting an appropriate working mode in a region-wise manner according to specific conditions of various regions, so that diversified demands of a user are satisfied, and the user does yard work more conveniently and is free from worry.