LYSENKO SERGEJ ALEKSANDROVICH,Лысенко Сергей Александрович,KUGEJKO MIKHAIL MIKHAJLOVICH,Кугейко Михаил Михайлович
申请号：
RU2013149215/14
公开号：
RU0002539367C1
申请日:
2013.11.05
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention refers to medicine and can be used to select individual radiation-measuring parameters of a laser therapy of an individuals tissues. The tissue is exposed to a broad-band visible and near-IR radiation. The tissue diffuse reflection spectrum is measured. The tissue diffuse reflection spectrum shows its structural-morphological parameters, including the tissue concentration of blood vessels fbl and photosensitiser Cps, as well as the relative blood contents of oxyhaemoglobin S and methaemoglobin CMetHb. The tissue spatial brightness spectrum F(z, λ) is stated with using a tissue optical radiation transfer model and the derived values of its structural-morphological parameters. Wave lengths and laser light powers, as well as the tissue exposure time providing the greatest light absorption by the photosensitiser and the best oxygen generation at a depth of a pathological segment of the tissue or throughout with the minimal exposure of the laser light on the healthy tissue are derived from distributed light absorption efficiency by the photosensitiser Kps(z, λ) and photochemical dissociation efficiency of oxyhaemoglobin n(z, λ) by the light wave length λ and the tissue depth z calculated by expressions: Kps(z, λ)=Cpsεps(λ)F(z, λ), n(z,λ)=fblS(CtHb/μtHb)εHbO2(λ)Ф(z,λ)(qλ/hc), wherein εps and εHbO2 are molar absorption coefficients by the photosensitiser and oxyhaemoglobin, CtHb=150 g/l is the average blood haemoglobin concentration, µtHb=64500 g/mole is the molar weight of haemoglobin, h is the Planks constant c is a light velocity in the medium q is a quantum yield of photochemical dissociation of oxyhaemoglobin.EFFECT: method enables determining the laser exposure parameters optimum for specific parameters, increasing the photodynamic therapeutic effectiveness and minimising the side effects of the treatment by monitoring the tissue concentration of the photosensitiser and oxyhaemoglobin, and the light absorption efficiency in the
