The invention relates to a composition containing phytic acid or a phytate salt magnesium in the form of salt hydroxide or oxide and optionally at least one polyphenol. These compounds can be in the isolated form or form part of an enriched plant extract. The invention also relates to the use of this composition for the treatment of renal lithiasis preferably calcium or oxocalcium in the form of a drug nutraceutical or functional food or food supplement.