БЛОМС-ФУНКЕ Петра (DE),ШИНЕ Клаус (DE),КРИСТОФ Томас (DE)
申请号：
RU2011112444/15
公开号：
RU2011112444A
申请日:
2009.09.04
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A combination containing as component (s):! (a) at least one 3- (3-dimethylamino-1-ethyl-2-methylpropyl) phenol of the formula (I),! ! if necessary, in the form of one of its stereoisomers, in particular the enantiomer or diastereomer, the racemate or in the form of a mixture of its stereoisomers, in particular enantiomers and / or diastereomers in any ratio of components, or any of its acid addition salts, and! (b) according to at least one antiepileptic agent. ! 2. The combination according to claim 1, characterized in that the compound of formula (I) is selected from! (1R, 2R) -3- (3-dimethylamino-1-ethyl-2-methylpropyl) phenol,! (1S, 2S) -3- (3-dimethylamino-1-ethyl-2-methylpropyl) phenol,! (1R, 2S) -3- (3-dimethylamino-1-ethyl-2-methylpropyl) phenol,! (1S, 2R) -3- (3-dimethylamino-1-ethyl-2-methylpropyl) phenol, and any mixture thereof. ! 3. The combination according to claim 2, characterized in that the compound of formula (I) is selected from! (1R, 2R) -3- (3-dimethylamino-1-ethyl-2-methylpropyl) phenol,! (1S, 2S) -3- (3-dimethylamino-1-ethyl-2-methylpropyl) phenol, and any mixture thereof. ! 4. The combination according to claim 2 or 3, characterized in that the compound of formula (I) is (1R, 2R) -3- (3-dimethylamino-1-ethyl-2-methylpropyl) -phenol of the formula (I '), ! ! or an acid addition salt thereof, with an acid hydrochloride salt being preferred. ! 5. The combination according to claim 1, characterized in that the antiepileptic agent is selected from the group consisting of methylphenobarbital, phenobarbital, primidone, barbexaclon, metarbital, ethothoin, phenytoin, amino (diphenylhydantoin) valerianic acid, mefenitoin, fenfenitinoid, , ethosuximide, fensuximide, mesuximide, clonazepam, carbamazepine, oxcarbazepine, eslikarbazepine, rufinamide,1. Комбинация, содержащая в качестве компонента (ов): ! (а) по меньшей мере, один 3-(3-диметиламино-1-этил-2-метилпропил)-фенол формулы (I), ! !при необходимости в виде одного из его стереоизомеров, в
