Human binding molecules capable of neutralizing influenza a viruses of phylogenetic group 1 and phylogenetic group 2 and influenza b viruses

• 收藏
• 分享

专利权人:

CRUCELL HOLLAND B.V.

发明人:

KWAKS THEODORUS HENDRIKUS JACOBUS,ZUIJDGEEST DAVID A.T.M.,VOGELS RONALD,FRIESEN ROBERT HEINZ EDWARD

申请号：

NZ61853012

公开号：

NZ618530A

申请日:

2012.07.12

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Discloses an isolated binding molecule, capable of specifically binding to an epitope in the stem region of the hemagglutinin protein (HA) of influenza A virus subtypes of phylogenetic group 1 and influenza A virus subtypes of phylogenetic group 2 subtypes, and capable of neutralizing influenza A virus subtypes of phylogenetic group 1 and phylogenetic group 2, characterized in that the binding molecule is also capable of specifically binding to the hemagglutinin protein (HA) of influenza B virus subtypes, wherein the binding molecule is selected from the group consisting of: a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:139, a heavy chain CDR2 region of SEQ ID NO:134, and a heavy chain CDR3 region of SEQ ID NO:145, and a light chain CDR1 region of SEQ ID NO: 146, a light chain CDR2 region of SEQ ID NO: 174, and a light chain CDR3 region of SEQ ID NO: 147, a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:139, a heavy chain CDR2 region of SEQ ID NO:134, and a heavy chain CDR3 region of SEQ ID NO:145, and a light chain CDR1 region of SEQ ID NO: 148, a light chain CDR2 region of SEQ ID NO: 149, and a light chain CDR3 region of SEQ ID NO: 150, a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:139, a heavy chain CDR2 region of SEQ ID NO:134, and a heavy chain CDR3 region of SEQ ID NO:145, and a light chain CDR1 region of SEQ ID NO: 142, a light chain CDR2 region of SEQ ID NO: 143, and a light chain CDR3 region of SEQ ID NO: 173 and a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:139, a heavy chain CDR2 region of SEQ ID NO:134, and a heavy chain CDR3 region of SEQ ID NO:152, and a light chain CDR1 region of SEQ ID NO: 148, a light chain CDR2 region of SEQ ID NO: 149, and a light chain CDR3 region of SEQ ID NO: 150, a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:139, a heavy chain CDR2 region of SEQ ID NO:134, and a heavy chain CDR3 region of SEQ ID NO:152, and a light c

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/