Patrick Soon-Shiong,Stephen Charles Benz,Andrew Nguyen,Shahrooz Rabizadeh,Kayvan Niazi,Oleksandr Buzko,Jay Gardner Nelson
申请号：
US15292095
公开号：
US20170028044A1
申请日:
2016.10.12
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Methods and compositions for preparation and use of recombinant viruses or other recombinant expression systems are presented in which neoepitopes are first identified in a patient- and cancer-specific manner and then further filtered by HLA-match to the patient. Selected neoepitopes are then expression using sequence elements that direct the expressed neoepitope to the HLA-type (MHC-I and/or MHC-II subtype) that has desirable affinity to the filtered neoepitope.
