NANTOMICS LLC;RABIZADEH Shahrooz;NGUYEN Andrew;BUZKO Oleksandr;NELSON Jay Gardner;BENZ Stephen Charles;NIAZI Kayvan;SOON-SHIONG Patrick
发明人:
SOON-SHIONG Patrick,NGUYEN Andrew,NIAZI Kayvan,RABIZADEH Shahrooz,BENZ Stephen Charles,BUZKO Oleksandr,NELSON Jay Gardner
申请号：
IL25868818
公开号：
IL258688D0
申请日:
2018.04.12
申请国别(地区):
IL
年份:
2018
代理人:
摘要：
Methods and compositions for preparation and use of recombinant viruses or other recombinant expression systems are presented in which neoepitopes are first identified in a patient- and cancer-specific manner and then further filtered by HLA-match to the patient. Selected neoepitopes are then expression using sequence elements that direct the expressed neoepitope to the HLA-type (MHC-I and/or MHC-II subtype) that has desirable affinity to the filtered neoepitope.
