The purpose of the present invention is to provide a novel AMP-activated protein kinase (AMPK) activator with a high safety. An AMPK activator that comprises a liver hydrolysate as an active ingredient.本發明提供一種安全性較高之新穎AMPK活化劑。本發明之AMP活化蛋白質激酶活化劑係以肝臟水解物作為有效成分。