592825 Disclosed is 6-((S)-I-(6-(I-methyl-IH-pyrazol-4-yl)-[1,2,4]triazolo[3,4-b ][1,3,4]thiadiazol-3-yl)ethyl)quinoline (compound 1). Aldo disclosed are compositions comprising compound 1 and the use of compound 1 for the manufacture of a medicament for treating or lessening the severity of a proliferative disorder in a patient, in particular glioblastoma; a gastric carcinoma; or a cancer selected from colon, breast, prostate, brain, liver, pancreatic or lung cancer.