THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
发明人:
MUTHUMANI, KARUPPIAH,WEINER, DAVID
申请号：
CA3015792
公开号：
CA3015792A1
申请日:
2017.02.24
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
An aspect of the present invention is related to nucleic acid constructs capable of expressing a Zika antigen that elicits an immune response in a mammal against Zika virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a Zika virus, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a Zika antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal that is cross reactive against all Zika strains.
