<;P>;PROBLEM TO BE SOLVED: To provide a method for producing a keratinocyte and/or an artificial epidermis sheet that is intended for the purposes of regeneration of skin tissue from a stem cell by differentiation-induction promoting effects from a stem cell to the keratinocyte; to provide a method for regenerating the skin using these. <;P>;SOLUTION: Remarkable promotion of differentiation induction from a stem cell to a keratinocyte by using seed extract of Sterculia scaphigera Wall belonging to Sterculiaceae allows extremely efficient production of a keratinocyte or an artificial epidermis sheet from a stem cell. The produced keratinocyte or artificial epidermis sheet also remarkably improves tissue regeneration ability upon transplantation to skin tissue. Therefore, this invention can widely contribute to the field of tissue regeneration and is expected to apply to the fields of medical science, medicaments, quasi drugs, beauty and health. <;P>;COPYRIGHT: (C)2010,JPO&INPIT