Described herein are methods of coating both metallic and polymeric surfaces adding hydrophilicity comprising the steps mixing a coating composition comprising at least one polyol, at least one compound having at least two isocyanate groups, and an organic solvent； introducing nucleophilic functional groups on the surface thereby creating an active surface； subjecting the active surface to the coating composition thereby forming a coated surface； and curing the coated surface. Medical devices, for example, implantable medical devices can be coated by the methods described herein.
