The present invention relates to a new use of an immunomodulatory protein derived fromGanodermaor a recombinant or a composition thereof in reducing damage caused by fine particulate matter on embryos and offspring. Accordingly, the present invention suggests that theGanodermaimmunomodulatory protein administrated to pregnant animals can prevent neurological damages and reduce risk of disorders in embryos and offspring.本發明涉及來源於靈芝(Ganoderma)的免疫調節蛋白或其重組體或組合物在減少由細顆粒物質所導致的對胚胎和子代的損傷中的新用途。因此，本發明表明投與到妊娠動物的所述靈芝免疫調節蛋白可以預防胚胎和子代的神經損傷並且降低所述胚胎和子代的病症的風險。
