新穎之VISTA-IG構築體及VISTA-IG用於治療自體免疫、過敏及發炎病症之用途农业专利-农业学术服务平台

发明人:: NOELLE, RANDOLF J.,诺伊里　蓝道夫Ｊ,諾伊里　藍道夫Ｊ,CEERAZ, SABRINA,席瑞兹　萨布里纳,席瑞茲　薩布里納,LEMERCIER, ISABELLE,拉莫契尔　伊沙贝尔,拉莫契爾　伊沙貝爾,NOWAK, ELIZABETH,诺渥克　伊莉沙白,諾渥克　伊莉沙白,LINES, JANET (LOUISE),莱恩斯　珍尼特（露易斯）,萊恩斯　珍尼特（露易斯）

摘要：: The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig), preferably also containing a flexible linker intervening the VISTA and Ig Fc polypeptide. The invention also provides the use of VISTA polypeptides, multimeric VISTA polypeptides, VISTA-conjugates (e.g., VISTA-Ig), and VISTA antagonists for the treatment of autoimmune disease, allergy, and inflammatory conditions, especially lupus, multiple sclerosis, psoriasis, psoriatic arthritis, multiple sclerosis, Crohn’s disease, inflammatory bowel disease and type 1 or type 2 diabetes.本發明係關於一種融合蛋白質，其包含調節性T細胞蛋白質VISTA(T細胞活化之V域免疫球蛋白抑制因子(PD-L3))及免疫球蛋白蛋白質(Ig)，較佳亦含有介於VISTA與Ig Fc多肽之間的柔性連接子。本發明亦提供VISTA多肽、多聚VISTA多肽、VISTA結合物(例如VISTA-Ig)及VISTA拮抗劑之用途，其用於治療自體免疫疾病、過敏及發炎病狀，尤其狼瘡、多發性硬化症、牛皮癬、牛皮癬性關節炎、多發性硬化症、克羅恩氏病、發炎性腸病及1型或2型糖尿病。