The present invention relates to a composition for photodynamic therapy of cancer diseases using a gene expressing a fluorescent protein and a photosensitizer, and a photodynamic therapy method using the same. More specifically, the present invention provides a composition for photodynamic therapy capable of selectively killing cancer cells only without affecting normal cells by treating the cancer cells, into which various fluorescent proteins have been introduced, with a photosensitizer and then irradiating a light source to the cancer cells, and a photodynamic therapy method using the same.
