PROBLEM TO BE SOLVED: To provide a peptide having no cytotoxicity and having tyrosinase inhibitory activity, a composition or an enzyme hydrolyzate for rice bran protein each containing the peptide.SOLUTION: The peptide is a peptide (a) containing a specific amino acid sequence, a peptide (b) containing the amino acid sequence of (a) in which one or several amino acids are substituted, deleted, inserted or added in amino acid residues other than the tyrosine residue at the C-terminal, the arginine residue at the fifth position from the C-terminal and the glutamic acid residue at the sixth position from the C-terminal, and having tyrosinase inhibitory activity, a peptide (c) containing another specified amino acid sequence, or a peptide (d) containing the amino acid sequence of (c) in which one or several amino acids are substituted, deleted, inserted or added in the amino acid residues other than the tyrosine residue at the C-terminal, and having tyrosinase inhibitory activity.COPYRIGHT: (C)2013,JPO&INPIT【課題】細胞毒性がなく、チロシナーゼ阻害活性を有するペプチド、該ペプチドを含む組成物又は米糠タンパク質の酵素加水分解物を提供すること。【解決手段】以下の(a)、(b)、(c)又は(d)のペプチド。(a)特定のアミノ酸配列を含むペプチド、(b)(a)のアミノ酸配列において、C末端のチロシン残基、C末端から5番目のアルギニン残基及びC末端から6番目のグルタミン酸残基以外のアミノ酸残基において、1~数個のアミノ酸が置換、欠失、挿入若しくは付加されたアミノ酸配列を含み、かつ、チロシナーゼ阻害活性を有するペプチド、(c)他の特定のアミノ酸配列を含むペプチド、又は(d)(c)のアミノ酸配列において、C末端のチロシン残基以外のアミノ酸残基において、1~数個のアミノ酸が置換、欠失、挿入若しくは付加されたアミノ酸配列を含み、かつ、チロシナーゼ阻害活性を有するペプチド【選択図】なし
