Adhesive composite system comprises an adhesive layer made from a tissue adhesive and a protective layer, which is applied on a surface of the adhesive layer, where: the tissue adhesive is based on hydrophilic polyurethane polymer and comprises (a) isocyanate functional prepolymer obtained from (a1) aliphatic isocyanate and (a2) polyol having average molecular weight of >= 400 g/mol and average hydroxyl functionality of 2-6, (b) aminofunctional aspartic acid ester (I) and/or (c) reaction product of (a) and (b) and the protective layer is water-proof layer. Adhesive composite system comprises an adhesive layer made from a tissue adhesive and a protective layer, which is applied on a surface of the adhesive layer, where: the tissue adhesive is based on hydrophilic polyurethane polymer and comprises (a) isocyanate functional prepolymer obtained from (a1) aliphatic isocyanate and (a2) polyol having average molecular weight of >= 400 g/mol and average hydroxyl functionality of 2-6, (b) aminofunctional aspartic acid ester of formula (X-[NH-CH(-CH 2-COOR2)-COOR1] n) (I) and/or (c) reaction product of (a) and (b) and the protective layer is water-proof layer. X : n-valent organic group that is obtained by removing a primary amino group of n-valent amine R1, R2 : organic residue comprising no Zerewitinoff-active hydrogen and n : at least 2. An independent claim is included for the preparation of the adhesive composite system comprising applying the adhesive layer made from the tissue adhesive on a substrate and applying the water-proof protective layer on the surface of the adhesive layer.本発明は、組織接着剤の接着剤層およびこの接着剤層の表面に適用する保護層とを含み、前記組織接着剤が親水性ポリウレタンポリマーに基づき、保護層が防水性である複合接着剤系に関する。また、本発明は、前記複合接着剤系の製造方法、その製造方法により得られる複合接着剤系、細胞組織を被覆、封止または結合させるために使用することのできる複合接着剤系、および細胞組織を被覆、封止または結合するための生成物の製造方法に関する。
