PROBLEM TO BE SOLVED: To provide a blood purifier which includes a hollow fiber membrane comprising a polysulfone-based polymer and polyvinylpyrrolidone, shows excellent performance to remove impurities in blood, and shows low albumin permeability and a low adsorbed amount of low-molecular-weight proteins.SOLUTION: The hollow fiber membrane includes a structure in which a pore diameter continuously increases from the inner surface of the membrane toward the outer surface of the membrane. The clearance value of vitamin B12 of the blood purifier after the irradiation with radiation is 152 mL/min or more per a membrane area of 1.5 m2 or in a conversion value of a membrane area of 1.5 m2. The adsorption rate of vitamin B12 is 25% or less, and the adsorption rate of myoglobin is 25% or less.COPYRIGHT: (C)2011,JPO&INPIT【課題】ポリスルホン系ポリマーとポリビニルピロリドンからなる中空糸膜を有する血液浄化器であって、血液中不純物の除去性能が高く、且つアルブミン透過率並びに低分子タンパク質の吸着量が低い血液浄化器を提供する。【解決手段】中空糸膜は、膜内表面から膜外表面に向かって連続的に孔径が大きくなる構造を有し、放射線照射後の該血液浄化器のビタミンB12のクリアランス値が膜面積1.5m2当たり/又は膜面積1.5m2換算値で152ml/分以上であり、ビタミンB12の吸着率が25%以下、かつミオグロビンの吸着率が25%以下である。【選択図】なし
