The present invention relates to multi-wavelength phototherapy devices, systems and methods for the treatment of a disorder or disease, including low-wavelength (pbm) phototherapy, particularly multi-wavelength pbm. phototherapy and other phototherapy systems and methods for enhancing functionality in and / or restoring functionality to a cell or tissue by coordinated and directed application to the cell or tissue of two or more light doses having different light wavelengths The two or more doses of light, when released in a coordinated manner, can stimulate the activity of two or more light-sensitive factors that, when activated, provide and / or enhance the desired functionality of the target cell. ophthalmic phototherapy devices and systems, and treatment methods for exposing an eye to multiple selected wavelengths of light to promote healing of diseased or damaged eye tissue. the devices include a compartment having an interior; an eyepiece disposed in the housing and configured and arranged to place an eye of the patient adjacent to the eyepiece; a first light source producing a first light beam having a first therapeutic wavelength disposed within the housing; a second light source producing a second beam of light having a second therapeutic wavelength arranged within the housing, wherein the second therapeutic wavelength differs from the first therapeutic wavelength by at least 25 nm.a presente invenção se refere a dispositivos, sistemas e métodos de fototerapia com múltiplos comprimentos de onda para o tratamento de um distúrbio ou doença, incluindo fototerapia de baixo nível com múltiplos comprimentos de onda ("pbm"), particularmente a pbm de múltiplos comprimentos de onda e outros sistemas e métodos de fototerapia para melhorar a funcionalidade em e/ou restaurar a funcionalidade a uma célula ou tecido, através da aplicação coordenada e direcionada à célula ou ao tecido de duas ou mais doses de luz tendo comprimentos de onda de luz distintos, sendo que as d