To provide an OPH activity enhancer which enhances activity of an OPH (oxidized protein degrading enzyme), the OPH accelerating degradation of an oxidized protein and saccharified protein, the so-called aging protein, and having a possibility to enable prevention and treatment of aging and diseases.SOLUTION: Provided is an OHP activity enhancer containing a pearl protein extract as an active ingredient. Also provided are food, food additive, medicine, quasi drug, cosmetics, and the like which contain such an OHP activity enhancer.SELECTED DRAWING: None【課題】酸化蛋白質や糖化蛋白質、いわゆる老化蛋白質などの分解を促進し、老化や疾患を予防・治療の可能性があるＯＰＨ（酸化蛋白質分解酵素）の活性を増強するＯＰＨ活性増強剤の提供。【解決手段】真珠タンパク抽出物を有効成分として含有するＯＰＨ活性増強剤。また、かかるＯＰＨ活性増強剤を含有するＯＰＨ活性増強用の食品、食品添加物、医薬品、医薬部外品及び化粧品。【選択図】なし
